姓 名：王俊文
性 别：男
最高学位：医学博士
职 称：医师
职 务：恩施州中心医院团委纪检委员、湖北硒与人体健康研究元PI
mail ： wang_jw001@163.com, wangjw95@mail2.sysu.edu.cn
电 话：18695028160
研究方向：眼遗传病
个人简介：
王俊文，中共党员，眼科学博士，博士毕业于中山大学中山眼科中心，是恩施州中心医院为了加强该院眼科中心国家临床重点专科建设和湖北省眼遗传病临床研究中心发展所引进的高层次和急需紧缺人才，现任恩施州中心医院团委纪检委员、湖北硒与人体健康研究院PI，专注眼遗传病的临床和基础研究。
承担的科学研究项目、教学研究项目及经费：
恩施州中心医院实验室PI科研启动项目 主持 20万
恩施州“启航专项”科技计划项目 主持 6万
恩施州中心医院国家自然科学基金培育项目 主持 5万
公开发表论文、教材、专著及课程建设：
1.Wang J, Li S, Jiang Y, Wang Y, Ouyang J, Yi Z, Sun W, Jia X, Xiao X, Wang P, Zhang Q. Pathogenic Variants in CEP290 or IQCB1 Cause Earlier-Onset Retinopathy in Senior-Loken Syndrome Compared to Those in INVS, NPHP3, or NPHP4. Am J Ophthalmol. 2023 Mar 27;252:188-204. doi: 10.1016/j.ajo.2023.03.025. PMID: 36990420.
2.Wang J, Wang Y, Li S, Xiao X, Yi Z, Jiang Y, Li X, Jia X, Wang P, Jin C, Sun W, Zhang Q. Clinical and Genetic Analysis of RDH12-Associated Retinopathy in 27 Chinese Families: A Hypomorphic Allele Leads to Cone-Rod Dystrophy. Invest Ophthalmol Vis Sci. 2022 Aug 2;63(9):24. doi: 10.1167/iovs.63.9.24. PMID: 35994252.
3. Wang J, Wang Y, Jiang Y, Li X, Xiao X, Li S, Jia X, Sun W, Wang P, Zhang Q. Autosomal Dominant Retinitis Pigmentosa-Associated TOPORS Protein Truncating Variants Are Exclusively Located in the Region of Amino Acid Residues 807 to 867. Invest Ophthalmol Vis Sci. 2022 May 2;63(5):19. doi: 10.1167/iovs.63.5.19. PMID: 35579903.
4.Wang J, Xiao X, Li S, Jiang H, Sun W, Wang P, Zhang Q. Landscape of pathogenic variants in six pre-mRNA processing factor genes for retinitis pigmentosa based on large in-house data sets and database comparisons. Acta Ophthalmol. 2022 Nov;100(7):e1412-e1425. doi: 10.1111/aos.15104. Epub 2022 Feb 9. PMID: 35138024.
5.Wang J, Wang Y, Jiang Y, Li S, Jia X, Xiao X, Sun W, Wang P, Zhang Q. Datasets-Based IMPDH1 Revisited: Heterozygous Missense Variants for Dominant Retinitis Pigmentosa While Truncation Variants Are Likely Non-Pathogenic. Curr Eye Res. 2024 Apr 11:1-9. doi: 10.1080/02713683.2024.2336158. Epub ahead of print. PMID: 38604988.
6.Wang J, Xiao X, Li S, Wang P, Sun W, Zhang Q. Dominant RP in the Middle While Recessive in Both the N- and C-Terminals Due to RP1 Truncations: Confirmation, Refinement, and Questions. Front Cell Dev Biol. 2021 Feb 19;9:634478. doi: 10.3389/fcell.2021.634478. PMID: 33681214.
7.Wang J, Liu F, Song X, Li T. Association of 5p15.2 and 15q14 with high myopia in Tujia and Miao Chinese populations. BMC Ophthalmol. 2020 Jun 26;20(1):255. doi: 10.1186/s12886-020-01516-8. PMID: 32586281.
8.Liu F, Wang J, Xing Y, Li T. Mutation screening of 17 candidate genes in a cohort of 67 probands with early-onset high myopia. Ophthalmic Physiol Opt. 2020 May;40(3):271-280. doi: 10.1111/opo.12683. Epub 2020 Mar 25. PMID: 32215939.
9.Wang Y, Wang J, Jiang Y, Zhu D, Ouyang J, Yi Z, Li S, Jia X, Xiao X, Sun W, Wang P, Zhang Q. New Insight into the Genotype-Phenotype Correlation of PRPH2-Related Diseases Based on a Large Chinese Cohort and Literature Review. Int J Mol Sci. 2023 Apr 4;24(7):6728. doi: 10.3390/ijms24076728. PMID: 37047703; PMCID: PMC10095211.
10.Sun W, Xiong D, Ouyang J, Xiao X, Jiang Y, Wang Y, Li S, Xie Z, Wang J, Tang Z, Zhang Q. Altered chromatin topologies caused by balanced chromosomal translocation lead to central iris hypoplasia. Nat Commun. 2024 Jun 13;15(1):5048. doi: 10.1038/s41467-024-49376-w. PMID: 38871723.
11.Zhu D, Wang J, Wang Y, Jiang Y, Li S, Xiao X, Wang P, Zhang Q. Variant Landscape of 15 Genes Involved in Corneal Dystrophies: Report of 30 Families and Comprehensive Analysis of the Literature. Int J Mol Sci. 2023 Mar 6;24(5):5012. doi: 10.3390/ijms24055012. PMID: 36902444.
12.Wang P, Wu P, Wang J, Zeng Y, Jiang Y, Wang Y, Li S, Xiao X, Zhang Q. Missense Mutations in MAB21L1: Causation of Novel Autosomal Dominant Ocular BAMD Syndrome. Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):19. doi: 10.1167/iovs.64.3.19. PMID: 36892533.
13.Jiang Y, Zhou L, Wang Y, Ouyang J, Li S, Xiao X, Jia X, Wang J, Yi Z, Sun W, Jiao X, Wang P, Hejtmancik JF, Zhang Q. The Genetic Confirmation and Clinical Characterization of LOXL3-Associated MYP28: A Common Type of Recessive Extreme High Myopia. Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):14. doi: 10.1167/iovs.64.3.24. PMID: 36917121.
14.Wang Y, Sun W, Xiao X, Jiang Y, Ouyang J, Wang J, Yi Z, Li S, Jia X, Wang P, Hejtmancik JF, Zhang Q. Unique Haplotypes in OPN1LW as a Common Cause of High Myopia With or Without Protanopia: A Potential Window Into Myopic Mechanism. Invest Ophthalmol Vis Sci. 2023 Apr 3;64(4):29. doi: 10.1167/iovs.64.4.29. PMID: 37097228.
15.Wang Y, Jiang Y, Wang J, Li S, Jia X, Xiao X, Sun W, Wang P, Zhang Q. Retinopathy as an initial sign of hereditary immunological diseases: report of six families and challenges in eye clinic. Front Immunol. 2023 Aug 28;14:1239886. doi: 10.3389/fimmu.2023.1239886. PMID: 37711606.
16.Li X, Wang Y, Wang J, Wang P, Zhang Q. Double Hyperautofluorescence Rings as a Sign of CFAP410-related Retinopathy. Invest Ophthalmol Vis Sci. 2023 Dec 1;64(15):44. doi: 10.1167/iovs.64.15.44. PMID: 38153748.
17.Guo D, Li S, Xiao X, Jiang Y, Wang Y, Jin G, Wang J, Ouyang J, Jia X, Sun W, Wang P, Zheng D, Zhang Q. Clinical and Genetic Landscape of Ectopia Lentis Based on a Cohort of Patients From 156 Families. Invest Ophthalmol Vis Sci. 2024 Jan 2;65(1):20. doi: 10.1167/iovs.65.1.20. PMID: 38190127.
18.Zheng Y, Wang Y, Jiang Y, Wang J, Li S, Xiao X, Sun W, Wang P, Zhang Q, Jia X. Variant and clinical landscape of Leber hereditary optic neuropathy based on 1516 families with mtDNA variants in a tertiary centre. Br J Ophthalmol. 2024 Feb 12:bjo-2023-323557. doi: 10.1136/bjo-2023-323557. Epub ahead of print. PMID: 38346855.
19.王俊文,肖紫云,李拓.巩膜扣带术治疗孔源性视网膜脱离的疗效及其对眼球生物学参数的影响[J].天游8线路检测中心学报(医学版),2020,37(01):30-34.DOI:10.13501/j.cnki.42-1590/r.2020.01.008. 2020-03-20
20.王俊文,李拓.多焦视网膜电图在视网膜疾病中的应用进展[J].国际眼科杂志,2020,20(10):1730-1735. 2020-10-08. DOI:10.3980 / j.issn.1672-5123.2020.10.14